This indicates the large potential for future bioprocess development considering the possible application of bioprocessing technological aspects for renewable energy storage and power generation.īiomethane bioreactor design media demands methanogens physiological parameters power to gas quantification scale-up. The much underexplored number of different genera, which is mainly limited to Methanothermobacter spp., offers the possibility of additional scientific and bioprocess development endeavors for the investigation of BMP. Most crucial parameters have been found to be those, which influence gas-limitation fundamentals, or parameters that contribute to the complex effects that arise during medium development for scale-up of BMP bioprocesses, highly stressing the importance of holistic BMP quantification by the application of well-defined physiological parameters. Moreover, industrial-based scale-up of BMP to pilot scale and larger has not been conducted. 9 This introduced a new level of control since Penicillium spp., unlike Clostridium spp., require oxygen to grow and the technology for. The major advance in bioprocess development which occurred during World War 2 was the large scale production and purification of penicillin, 8 using the Penicillium mould discovered nearly 20 years earlier. However, some promising alternatives, such as membrane reactors have already been adapted for BMP. Kim Gail Clarke, in Bioprocess Engineering, 2013. This review shows that BMP is currently a much underexplored field of bioprocess development, which mainly focuses on the application of continuously stirred tank reactors. The prerequisites for successful quantification of BMP by using closed batch, as well as fed-batch and chemostat culture cultivation, are presented.

This review summarizes the current state of the art of bioprocess development for biological CH4 production (BMP) from pure cultures with pure gasses. One opportunity is to utilize carbon dioxide (CO2)-type hydrogenotrophic methanogens, which are an intriguing group of microorganisms from the domain Archaea, for conversion of hydrogen and CO2 to methane (CH4). The production and storage of energy from renewable resources steadily increases in importance.

Bioprocess development